A marathoner-in-training on my team couldn't understand why she had been really tired and sluggish the day after her long training runs. After some routine blood tests, she found out that she's borderline deficient in both iron and B12, which helps explains her exhaustion.
...Source: http://running.about.com/b/2011/08/26/feeling-sluggish-after-your-long-runs.htm
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